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Vitamin K to Correct Overanticoagulation
TO THE EDITOR:
Crowther and colleagues (1) raise an important management question regarding a common clinical problem: What do we do with patients who are not bleeding but who have prolonged INR between 4.5 and 10.0 while taking warfarin?
Although the study showed administering oral vitamin K, 1.25 mg, to be statistically significantly more effective in decreasing INR to the therapeutic range than just withholding 1 dose of warfarin, the conclusion was that “[l]ow-dose oral vitamin K did not reduce bleeding in warfarin recipients with INRs of 4.5 to 10.0.” …
This 100-word excerpt has been provided in the absence of an abstract.
