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Vitamin K to Correct Overanticoagulation
TO THE EDITOR:
In their recent study on managing supratherapeutic warfarin administration with or without vitamin K, Crowther and colleagues (1) use flawed methodology to arrive at what may be an apocryphal conclusion, which is that vitamin K therapy has no role in managing patients with high international normalized ratios (INRs).
The study uses a commercially unavailable vitamin K preparation. The pharmacokinetics and effectiveness of this preparation have not been clinically validated.
Confronted with overanticoagulation, clinicians explore recent relevant events; exclude patient dosing errors; consider vitamin K; and …
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