Table of Contents

August 18, 2009; 151 (4)

Articles

  • Positron Emission Tomography in Staging Early Lung Cancer: A Randomized Trial

    • Donna E. Maziak,
    • Gail E. Darling,
    • Richard I. Inculet,
    • Karen Y. Gulenchyn,
    • Albert A. Driedger,
    • Yee C. Ung,
    • John D. Miller,
    • Chu-Shu Gu,
    • Kathryn J. Cline,
    • William K. Evans,
    • and Mark N. Levine
    Ann Intern Med August 18, 2009 151:221-228; doi:10.1059/0003-4819-151-4-200908180-00132

    Maziak and colleagues compared 2 preoperative imaging strategies for patients with early non–small cell lung cancer: whole-body positron emission tomography and computed tomography (PET-CT) plus cranial imaging versus conventional staging plus cranial imaging. Trial results suggested that compared with conventional staging, a PET-CT–based imaging strategy may help identify advanced disease and prevent futile thoracotomy in patients with non–small cell lung cancer, but it also may give false-positive results that incorrectly upstage disease in some patients.

  • Comparison of Tripterygium wilfordii Hook F Versus Sulfasalazine in the Treatment of Rheumatoid Arthritis: A Randomized Trial

    • Raphaela Goldbach-Mansky,
    • Mildred Wilson,
    • Roy Fleischmann,
    • Nancy Olsen,
    • Joel Silverfield,
    • Phillip Kempf,
    • Alan Kivitz,
    • Yvonne Sherrer,
    • Frank Pucino,
    • Gyorgy Csako,
    • Rene Costello,
    • Tuyet Hang Pham,
    • Christopher Snyder,
    • Désirée van der Heijde,
    • Xuelian Tao,
    • Robert Wesley,
    • and Peter E. Lipsky
    Ann Intern Med August 18, 2009 151:229-240; doi:10.1059/0003-4819-151-4-200908180-00005

    In Chinese medicine, extracts of Tripterygium wilfordii Hook F (TwHF) are used to treat autoimmune and inflammatory conditions. Small clinical trials suggest that TwHF may benefit patients with rheumatoid arthritis. Goldbach-Mansky and associates compared TwHF extract with sulfasalazine in 121 patients with active rheumatoid arthritis who could continue use of oral prednisone and nonsteroidal anti-inflammatory drugs but not disease-modifying antirheumatic drugs. Among those who continued treatment for 24 weeks, achievement of 20% improvement in American College of Rheumatology criteria was greater with TwHF than with sulfasalazine, and adverse event rates were similar.

  • Five-Year Outcomes of the China National Free Antiretroviral Treatment Program

    • Fujie Zhang,
    • Zhihui Dou,
    • Ye Ma,
    • Yan Zhao,
    • Zhongfu Liu,
    • Marc Bulterys,
    • and Ray Y. Chen
    Ann Intern Med August 18, 2009 151:241-251; doi:10.1059/0003-4819-151-4-200908180-00006

    In 2002, China began the National Free Antiretroviral Program, which provides highly active antiretroviral therapy (HAART) to eligible HIV-positive persons. Among 48 785 program participants over 5 years, mortality was highest in the 3 months after HAART initiation, decreased to 4 to 5 deaths per 100 person-years by 6 months, and stayed stable through year 5. The cumulative rate of immunologic treatment failure, which was measured by CD4 cell count, was 50% by year 5.

Academia and Clinic

  • The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

    • Alessandro Liberati,
    • Douglas G. Altman,
    • Jennifer Tetzlaff,
    • Cynthia Mulrow,
    • Peter C. Gøtzsche,
    • John P.A. Ioannidis,
    • Mike Clarke,
    • P. J. Devereaux,
    • Jos Kleijnen,
    • and David Moher
    Ann Intern Med August 18, 2009 151:W-65-W-94; doi:10.1059/0003-4819-151-4-200908180-00136

    Liberati and colleagues present an explanation and elaboration of the PRISMA Statement, updated guidelines for the reporting of systematic reviews and meta-analyses. This article is available online only.

  • Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

    • David Moher,
    • Alessandro Liberati,
    • Jennifer Tetzlaff,
    • Douglas G. Altman,
    • and the PRISMA Group
    Ann Intern Med August 18, 2009 151:264-269; doi:10.1059/0003-4819-151-4-200908180-00135

    Moher and colleagues introduce PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses. Using a systematic review of studies examining the quality of reporting of systematic reviews, a comprehensive literature search to identify methodological and other articles, and results of an international survey, the executive committee revised and expanded the QUOROM checklist and flow diagram.

Review

  • Systematic Review: Elective Induction of Labor Versus Expectant Management of Pregnancy

    • Aaron B. Caughey,
    • Vandana Sundaram,
    • Anjali J. Kaimal,
    • Allison Gienger,
    • Yvonne W. Cheng,
    • Kathryn M. McDonald,
    • Brian L. Shaffer,
    • Douglas K. Owens,
    • and Dena M. Bravata
    Ann Intern Med August 18, 2009 151:252-263; doi:10.1059/0003-4819-151-4-200908180-00007

    Caughey and colleagues conducted a systematic review of randomized trials and observational studies to compare the benefits and harms of elective induction of labor and expectant management of pregnancy. Available evidence suggests that elective induction of labor at 41 weeks of gestation and beyond is associated with a decreased risk for cesarean delivery and meconium-stained amniotic fluid.

Perspectives

  • Should We Be Applying Warfarin Pharmacogenetics to Clinical Practice? No, Not Now

    • Michael H. Rosove and
    • Wayne W. Grody
    Ann Intern Med August 18, 2009 151:270-273; doi:10.1059/0003-4819-151-4-200908180-00009

    In 2007, the U.S. Food and Drug Administration modified warfarin prescribing information to suggest, but not to mandate, pharmacogenetic testing to guide dosing. Rosove and Grody ask whether we should now be applying warfarin pharmacogenetics routinely to clinical practice. They discuss that results predict only one third of all dosing variation, the value of testing in reducing bleeding and thrombosis rates remains unproved, and cost-effectiveness is not established.

History of Medicine

  • The Death of Wolfgang Amadeus Mozart: An Epidemiologic Perspective

    • Richard H.C. Zegers,
    • Andreas Weigl,
    • and Andrew Steptoe
    Ann Intern Med August 18, 2009 151:274-278; doi:10.1059/0003-4819-151-4-200908180-00010

    Zegers and colleagues examined all recorded deaths in Vienna at the time of the death of the composer Wolfgang Amadeus Mozart. It has been suggested that Mozart's death was due to poisoning, renal failure, Henoch–Schönlein purpura, trichinosis, and many other conditions. After examining the causes of death of persons who died in Vienna, the authors conclude that Mozart's death was due to a streptococcal infection leading to an acute nephritic syndrome caused by poststreptococcal glomerulonephritis. Scarlet fever is a less likely possibility.

Editorials

  • The PET and the Pendulum

    • Mitchell L. Margolis
    Ann Intern Med August 18, 2009 151:279-280; doi:10.1059/0003-4819-151-4-200908180-00134

    Use of PET and CT for noninvasive detection of distant metastatic disease in lung cancer has been validated by many detailed studies, including Maziak and colleagues' study in this issue. Given accumulated evidence, it is reasonable to order PET-CT for lung cancer staging, especially for patients who seem to be candidates for curative therapy.

  • Elective Induction of Labor: Waking the Sleeping Dogma?

    • George A. Macones
    Ann Intern Med August 18, 2009 151:281-282; doi:10.1059/0003-4819-151-4-200908180-00012

    Caughey and colleagues' systematic review in this issue reports on the effect of elective induction of labor on cesarean birth rates and relevant maternal and neonatal outcomes. The review supports the notion that elective induction at 41 weeks and beyond reduces the rate of cesarean birth and meconium-stained amniotic fluid. It should spur obstetricians to rethink and, more important, to more carefully research the role of elective induction of labor at and beyond 39 weeks.

On Being a Patient

  • Medical Mystery, Medical Humility

    • Gordon Mehler and
    • Ariel Zwang
    Ann Intern Med August 18, 2009 151:283-284; doi:10.1059/0003-4819-151-4-200908180-00013

    “To be a good doctor, sometimes you must envision yourself as slightly stupid.” When a physician friend told us this after our 9-year-old, Grace, mysteriously got very sick, the thought was hardly comforting. But when various specialists were stumped by our daughter's condition, we came to understand what he meant.

Letters

  • Comments on the Recent Clinical Guidance Statement on HIV Screening

    • Eliezer M. Van Allen and
    • R. Jeffrey Kohlwes
    Ann Intern Med August 18, 2009 151:286; doi:10.1059/0003-4819-151-4-200908180-00015

  • Comments on the Recent Clinical Guidance Statement on HIV Screening

    • David R. Holtgrave
    Ann Intern Med August 18, 2009 151:286-287; doi:10.1059/0003-4819-151-4-200908180-00016

  • Comments on the Recent Clinical Guidance Statement on HIV Screening

    • Amir Qaseem,
    • Paul Shekelle,
    • and Douglas K. Owens
    Ann Intern Med August 18, 2009 151:287; doi:10.1059/0003-4819-151-4-200908180-00017

  • The Professional Testing Center: Past and Present

    • Christine K. Cassel
    Ann Intern Med August 18, 2009 151:287-288; doi:10.1059/0003-4819-151-4-200908180-00018

  • Does B-Type Natriuretic Peptide Testing Affect Outcome and Management of Patients With Acute Dyspnea?

    • Mihály Tapolyai
    Ann Intern Med August 18, 2009 151:288; doi:10.1059/0003-4819-151-4-200908180-00019

  • Does B-Type Natriuretic Peptide Testing Affect Outcome and Management of Patients With Acute Dyspnea?

    • Ajay Pachika,
    • Malek Numeir,
    • and Kiranmayi Adimoolam
    Ann Intern Med August 18, 2009 151:288-289; doi:10.1059/0003-4819-151-4-200908180-00020

  • Does B-Type Natriuretic Peptide Testing Affect Outcome and Management of Patients With Acute Dyspnea?

    • Franca Dipaola,
    • Francesca Perego,
    • Monica Solbiati,
    • Giovanni Casazza,
    • and on behalf of the Gruppo di Autoformazione Metodologica
    Ann Intern Med August 18, 2009 151:289; doi:10.1059/0003-4819-151-4-200908180-00021

  • Does B-Type Natriuretic Peptide Testing Affect Outcome and Management of Patients With Acute Dyspnea?

    • Hans-Gerhard Schneider,
    • Louisa Lam,
    • and Peter Cameron
    Ann Intern Med August 18, 2009 151:289-290; doi:10.1059/0003-4819-151-4-200908180-00022

  • A Novel Maneuver to Prevent Median Nerve Injury in Phlebotomy

    • Hiroaki Ohnishi,
    • Tsuyoshi Urata,
    • Tomonori Kishino,
    • Maiko Takano,
    • and Takashi Watanabe
    Ann Intern Med August 18, 2009 151:290-291; doi:10.1059/0003-4819-151-4-200908180-00023

  • Correction: Prevalence of Cognitive Impairment Without Dementia

    Ann Intern Med August 18, 2009 151:291-292; doi:10.1059/0003-4819-151-4-200908180-00024

  • Correction: In The Clinic: Tuberculosis

    Ann Intern Med August 18, 2009 151:292; doi:10.1059/0003-4819-151-4-200908180-00025

Current Clinical Issues

  • Making Electronic Health Records Meaningful

    • Jennifer Fisher Wilson
    Ann Intern Med August 18, 2009 151:293-296; doi:10.1059/0003-4819-151-4-200908180-00026

Ad Libitum

  • Dissection

    • Kristin N. Ray
    Ann Intern Med August 18, 2009 151:285; doi:10.1059/0003-4819-151-4-200908180-00014

Medical Notices

  • Medical Notices

    Ann Intern Med August 18, 2009 151:0; doi:10.1059/0003-4819-151-4-200908190-00027

Summaries for Patients

  • Positron Emission Tomography Plus Computed Tomography for Staging Early Lung Cancer

    Ann Intern Med August 18, 2009 151:I-21; doi:10.1059/0003-4819-151-4-200908180-00133

  • The Chinese Herbal Remedy Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Arthritis

    Ann Intern Med August 18, 2009 151:I-36; doi:10.1059/0003-4819-151-4-200908180-00002

  • Five-Year Outcomes of the China National Free Antiretroviral Treatment Program

    Ann Intern Med August 18, 2009 151:I-42; doi:10.1059/0003-4819-151-4-200908180-00003

ACP Journal Club

  • Editorial: Writing a research article that is “fit for purpose”: EQUATOR Network and reporting guidelines

    Ann Intern Med August 18, 2009 151:JC2-2; doi:10.1059/0003-4819-151-4-200908180-02002

  • Review: Intensive insulin therapy increases risk for hypoglycemia but not mortality in critically ill adults

    Ann Intern Med August 18, 2009 151:JC2-4; doi:10.1059/0003-4819-151-4-200908180-02004

  • Intensive glucose control increased risk for death and severe hypoglycemia in critically ill adults

    Ann Intern Med August 18, 2009 151:JC2-5; doi:10.1059/0003-4819-151-4-200908180-02005

  • Review: Diabetes is not a coronary disease equivalent

    Ann Intern Med August 18, 2009 151:JC2-6; doi:10.1059/0003-4819-151-4-200908180-02006

  • Screening for CAD in asymptomatic patients with type 2 diabetes did not reduce risk for cardiac events

    Ann Intern Med August 18, 2009 151:JC2-7; doi:10.1059/0003-4819-151-4-200908180-02007

  • Review: Oral vitamin D prevents nonvertebral and hip fractures in a dose-dependent manner in patients  65 years of age

    Ann Intern Med August 18, 2009 151:JC2-8; doi:10.1059/0003-4819-151-4-200908180-02008

  • Review: Aldosterone blockade reduces mortality in patients with left ventricular dysfunction

    Ann Intern Med August 18, 2009 151:JC2-9; doi:10.1059/0003-4819-151-4-200908180-02009

  • Esomeprazole did not improve asthma symptoms in poorly controlled asthma

    Ann Intern Med August 18, 2009 151:JC2-10; doi:10.1059/0003-4819-151-4-200908180-02010

  • Review: Combining 2 classes of blood pressure–lowering drugs has an approximately additive effect on systolic blood pressure

    Ann Intern Med August 18, 2009 151:JC2-11; doi:10.1059/0003-4819-151-4-200908180-02011

  • Both typical and atypical antipsychotic agents were associated with increased risk for sudden cardiac death

    Ann Intern Med August 18, 2009 151:JC2-12; doi:10.1059/0003-4819-151-4-200908180-02012

  • Concomitant use of proton pump inhibitors with clopidogrel may increase risk for readmission after discharge for acute MI

    Ann Intern Med August 18, 2009 151:JC2-13; doi:10.1059/0003-4819-151-4-200908180-02013

  • Bariatric surgery was cost-effective at 2 years for management of type 2 diabetes in obese patients

    Ann Intern Med August 18, 2009 151:JC2-14; doi:10.1059/0003-4819-151-4-200908180-02014

  • Bariatric surgery was dominant over conventional therapy for lifetime management of type 2 diabetes in obese patients

    Ann Intern Med August 18, 2009 151:JC2-15; doi:10.1059/0003-4819-151-4-200908180-02015

  • Glossary

    Ann Intern Med August 18, 2009 151:JC2-16; doi:10.1059/0003-4819-151-4-200908180-02016
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This Issue

August 18, 2009; 151 (4)
  1. Articles
  2. Academia and Clinic
  3. Review
  4. Perspectives
  5. History of Medicine
  6. Editorials
  7. On Being a Patient
  8. Letters
  9. Current Clinical Issues
  10. Ad Libitum
  11. Medical Notices
  12. Summaries for Patients
  13. ACP Journal Club

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