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Hepatitis B Virus Reactivation in a Patient With Resolved Hepatitis B Virus Infection Receiving Maintenance Rituximab for Malignant B-Cell Lymphoma
- Yu Xuan Koo;
- Daniel S.W. Tan, MBBS;
- Iain B. Tan, MBBS;
- Miriam Tao, MBBS; and
- Soon Thye Lim, MBBS
- From Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, and National Cancer Centre Singapore, Singapore 169610.
Background: The risk for hepatitis B virus (HBV) reactivation in patients with seemingly resolved infection who are undergoing treatment for cancer remains controversial.
Objective: To report a case of HBV reactivation in a patient with seemingly resolved infection who was undergoing lymphoma treatment.
Case Report: A 71-year-old man with mantle cell lymphoma had previously resolved hepatitis B virus (HBV) infection, defined as negative HBV surface antigen (HBsAg) with detectable antibody to HBV core antigen (anti-HBc). He had no detectable antibody to HBsAg (anti-HBsAg). Full staging investigations showed multiple enlarged lymph nodes. An excision biopsy of the right axillary lymph node was performed, and immunohistochemistry highlighted a nodular lymphoid infiltrate of CD20+ B cells with strong nuclear cyclin D1 expression.
The patient …
This 100-word excerpt has been provided in the absence of an abstract.
