Can the SMART Study Data Be Used to Assess Risk Factors for Renal Disease?

  1. James D. Neaton, PhD; and
  2. for the INSIGHT SMART Study Group
  1. From University of Minnesota, Minneapolis, MN 55414.

    IN RESPONSE:

    We agree with Dr. Gupta that the renal outcomes before and after the protocol modification in SMART are interesting and require further study. The interaction P value corresponding to the treatment hazard ratio comparison before and after the protocol change was significant (P = 0.014); however, the number of participants with renal events, defined in SMART as death from renal disease or end-stage renal disease, …

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    1. Ann Intern Med February 17, 2009 vol. 150 no. 4 282-283
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