Lipid-lowering therapy is costly but effective at reducing coronary heart disease (CHD) risk. The authors used a probabilistic
model to show that the Adult Treatment Panel III guidelines, which recommend treatment based on cholesterol level and estimated
CHD risk, are reasonably cost-effective if statins cost about $1.50 to $2.20 per pill. At costs lower than $0.10 per pill,
treating everyone with low-density lipoprotein cholesterol levels greater than 3.4 mmol/L (>130 mg/dL), regardless of other
CHD risk factors, could be a better strategy.