Risk Prediction Versus Diagnosis: Preserving Clinical Nuance in a Binary World

  1. Benjamin Djulbegovic, MD, PhD
  1. From University of South Florida, Tampa, FL 33620.

    TO THE EDITOR:

    I read with great interest the article by Vickers and colleagues (1), in which they note the problem of diagnosis caused by difficulties in classification of borderline cases: One individual or very small differences in the quantities of interest may completely change categorization and consequent actions. Unfortunately, the risk prediction alternative recommended by the authors is unlikely to attenuate the problem of diagnosing diseases that are defined on …

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