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Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk
- Nina P. Paynter, PhD;
- Nancy R. Cook, ScD; and
- Paul M Ridker, MD, MPH
- From Brigham and Women's Hospital, Boston, MA 02215.
IN RESPONSE:
We appreciate the interest in our article and the opportunity to address readers' questions.
Drs. Gulcher and Stefannson bring up the distribution of risk in the study population. Although it is correct that the overall risk in our population is low, other variables have improved prediction in this cohort (1). We do not believe that examining the utility of 9p21 genotype in risk classification of a higher-risk population would necessarily show different results, and we look forward to analyses done in different …
