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Do Reference Standards Hold Back the Progress of Medicine?
- Paul Glasziou, MB, BS, PhD;
- Les Irwig, MB, MCh, PhD; and
- Jonathan Deeks, PhD
- From University of Oxford, Oxford OX3 7LF, United Kingdom; University of Sydney, Sydney, New South Wales 2006, Australia; and University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
IN RESPONSE:
Although we agree with Drs. Smulders and Thijs that researchers and clinicians should pay more attention to the changes in spectrum that may occur with new tests, we think that the ideas of reference standards and diagnosis will remain useful. Some new tests do clearly alter the spectrum of illness, which is why we emphasized the need to consider the clinical consequences of such …
