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Heterologous Fat Transplantation for the Treatment of HIV-Related Facial Lipoatrophy
- Giovanni Guaraldi, MD;
- Nicola Squillace, MD;
- Domenico De Fazio, MD;
- Tullio Prestileo, MD; and
- Frank Palella, MD
- From the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.
Background: Clinical features of HIV-1–related lipodystrophy prominently include facial lipoatrophy. These abnormalities can adversely affect the psychological well-being of HIV-infected individuals, affecting adherence to antiretroviral drug regimens, body self-image, and overall quality of life (1, 2).
Objective: To evaluate heterologous fat transplant to treat facial lipoatrophy in a set of HIV-serodiscordant homozygous twins and discuss its possible pathogenetic implications.
Case Report: We transplanted abdominal subcutaneous fat from twin 1, the HIV-seronegative donor, to the subcutaneous cheek region of twin 2, the HIV-infected recipient, by using the Coleman technique (3). Twin 2 had been HIV-infected for 18 years and was extensively treated with all 3 …
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