Table of Contents

October 7, 2008; 149 (7)

Articles

  • Stool DNA and Occult Blood Testing for Screen Detection of Colorectal Neoplasia

    • David A. Ahlquist,
    • Daniel J. Sargent,
    • Charles L. Loprinzi,
    • Theodore R. Levin,
    • Douglas K. Rex,
    • Dennis J. Ahnen,
    • Kandice Knigge,
    • M. Peter Lance,
    • Lawrence J. Burgart,
    • Stanley R. Hamilton,
    • James E. Allison,
    • Michael J. Lawson,
    • Mary E. Devens,
    • Jonathan J. Harrington,
    • and Shauna L. Hillman
    Ann Intern Med October 7, 2008 149:441-450

    Ahlquist and colleagues compared 2 stool DNA tests with fecal blood testing for detection of screen-relevant neoplasia in 4482 average-risk adults, using colonoscopy as the criterion standard. Stool DNA test 1 (SDT-1) provided no improvement over HemoccultSensa for detection of screen-relevant neoplasms, whereas SDT-2 detects significantly more neoplasms than does Hemoccult or HemoccultSensa but with more positive results in colonoscopically normal patients.

  • Association of Electrocardiographic Morphology of Exercise-Induced Ventricular Arrhythmia with Mortality

    • Robert E. Eckart,
    • Michael E. Field,
    • Tomasz W. Hruczkowski,
    • Daniel E. Forman,
    • Sharmila Dorbala,
    • Marcelo F. Di Carli,
    • Christine E. Albert,
    • William H. Maisel,
    • Laurence M. Epstein,
    • and William G. Stevenson
    Ann Intern Med October 7, 2008 149:451-460

    The prognostic value of exercise-induced ventricular arrhythmia (EIVA) is uncertain, and outcomes may depend on QRS morphology. Among 585 patients with and 2340 patients without EIVA who were matched by age, sex, and risk factor and underwent exercise testing, 5.3% and 1.8%, respectively, died over 24 months. However, only patients with right bundle-branch block morphology had a higher risk for death than those without EIVA.

  • Insulin-like Growth Factors, Their Binding Proteins, and Prostate Cancer Risk: Analysis of Individual Patient Data from 12 Prospective Studies

    • Andrew W. Roddam,
    • Naomi E. Allen,
    • Paul Appleby,
    • Timothy J. Key,
    • Luigi Ferrucci,
    • H. Ballentine Carter,
    • E. Jeffrey Metter,
    • Chu Chen,
    • Noel S. Weiss,
    • Annette Fitzpatrick,
    • Ann W. Hsing,
    • James V. Lacey, Jr,
    • Kathy Helzlsouer,
    • Sabina Rinaldi,
    • Elio Riboli,
    • Rudolf Kaaks,
    • Joop A.M.J.L. Janssen,
    • Mark F. Wildhagen,
    • Fritz H. Schröder,
    • Elizabeth A. Platz,
    • Michael Pollak,
    • Edward Giovannucci,
    • Catherine Schaefer,
    • Charles P. Quesenberry, Jr.,
    • Joseph H. Vogelman,
    • Gianluca Severi,
    • Dallas R. English,
    • Graham G. Giles,
    • Pär Stattin,
    • Göran Hallmans,
    • Mattias Johansson,
    • June M. Chan,
    • Peter Gann,
    • Steven E. Oliver,
    • Jeff M. Holly,
    • Jenny Donovan,
    • François Meyer,
    • Isabelle Bairati,
    • and Galan
    Ann Intern Med October 7, 2008 149:461-471

    Insulin-like growth factors (IGFs) and IGF binding proteins may be associated with some types of cancer. In this patient-level reanalysis of 12 studies including 3700 men with prostate cancer and 5200 control participants, the association found between IGFs and IGF binding proteins and prostate cancer suggests that higher levels of serum IGF-I are associated with higher risk for prostate cancer.

Improving Patient Care

  • The Effect of a Quality Improvement Collaborative to Improve Antimicrobial Prophylaxis in Surgical Patients: A Randomized Trial

    • Stephen B. Kritchevsky,
    • Barbara I. Braun,
    • Andrew J. Bush,
    • Michele R. Bozikis,
    • Linda Kusek,
    • John P. Burke,
    • Edward S. Wong,
    • John Jernigan,
    • Cralen C. Davis,
    • Bryan Simmons,
    • and for the TRAPE Study Group
    Ann Intern Med October 7, 2008 149:472-480

    Kritchevsky and coworkers assessed the effect of a quality improvement collaborative versus receipt of only a feedback report to improve prophylaxis of surgery-related infection. The 44 U.S. acute care hospitals that participated each randomly sampled approximately 100 selected surgical cases to evaluate whether and when patients received prophylaxis. The groups did not differ in the change in proportion of patients who received a properly timed antimicrobial prophylaxis dose or in individual measures of antibiotic duration.

Review

  • Systematic Review: d-Dimer to Predict Recurrent Disease after Stopping Anticoagulant Therapy for Unprovoked Venous Thromboembolism

    • Madeleine Verhovsek,
    • James D. Douketis,
    • Qilong Yi,
    • Sanjay Shrivastava,
    • R. Campbell Tait,
    • Trevor Baglin,
    • Daniela Poli,
    • and Wendy Lim
    Ann Intern Med October 7, 2008 149:481-490

    A test to identify persons at low risk for recurrent venous thromboembolism (VTE) could help with the decision to continue or stop anticoagulant treatment. This systematic review identified 7 studies that measured d-dimer 3 to 6 weeks after stopping treatment for a first unprovoked VTE. Recurrence rates within approximately 2 years were 8.9% and 3.5% in patients with a positive and negative d-dimer test result, respectively.

Clinical Guidelines

  • Behavioral Counseling to Prevent Sexually Transmitted Infections: U.S. Preventive Services Task Force Recommendation Statement

    • U.S. Preventive Services Task Force
    Ann Intern Med October 7, 2008 149:491-496

    The U.S. Preventive Services Task Force (USPSTF) has issued a new statement on recommendations about behavioral counseling of adolescents and adults to prevent sexuallytransmitted infections (STIs). They recommend high-intensity behavioral counseling for all sexually active adolescents and for adults at increased risk for STIs (B recommendation). Current evidence is insufficient to assess the balance of benefits and harms of behavioral counseling to prevent STIs in non–sexually active adolescents and in adults not at increased risk for STIs (I statement).

  • Behavioral Counseling to Prevent Sexually Transmitted Infections: A Systematic Review for the U.S. Preventive Services Task Force

    • Jennifer S. Lin,
    • Evelyn Whitlock,
    • Elizabeth O'Connor,
    • and Vance Bauer
    Ann Intern Med October 7, 2008 149:497-508

    To support the USPSTF recommendation in this issue, Lin and colleagues found good-quality evidence from 17 studies suggesting that behavioral counseling interventions with multiple sessions conducted in STI clinics and primary care effectively reduce STI incidence in at-risk adult and adolescent populations. Additional trial evidence is needed for lower-intensity behavioral counseling interventions and lower-risk patient populations.

Editorial

  • Stool DNA Testing and Colon Cancer Prevention: Another Step Forward

    • Daniel C. Chung
    Ann Intern Med October 7, 2008 149:509-510

    A noninvasive test that preselects individuals who are likely to have advanced adenomas or cancer for subsequent colonoscopy is a worthy goal. Ahlquist and colleagues' study in this issue provides exciting evidence that such an approach may be possible. In time, a few strands of DNA may be all it takes to deliver an ounce of prevention.

On Being a Doctor

Letters

  • Will Recommendations against Spirometry Make Chronic Obstructive Pulmonary Disease Harder to Treat?

    • Thomas L. Petty and
    • David M. Mannino
    Ann Intern Med October 7, 2008 149:512-513

  • Will Recommendations against Spirometry Make Chronic Obstructive Pulmonary Disease Harder to Treat?

    • Ned Calonge,
    • Diana B. Petitti,
    • and Kenneth Lin
    Ann Intern Med October 7, 2008 149:513

  • Did Prescription Bias Affect Outcomes in a Study of the Relative Effectiveness of Osteoporosis Drugs?

    • Abhimanyu Beri and
    • Saakshi Khattri
    Ann Intern Med October 7, 2008 149:514

  • Did Prescription Bias Affect Outcomes in a Study of the Relative Effectiveness of Osteoporosis Drugs?

    • Suzanne M. Cadarette,
    • Jeffrey N. Katz,
    • and Daniel H. Solomon
    Ann Intern Med October 7, 2008 149:514

  • The Effects of Race, Ethnicity, and Underlying Medical Diseases on Osteoporosis Are Still Unguided Territory for Internists

    • Brittany Bohinc and
    • John E. Snyder
    Ann Intern Med October 7, 2008 149:514-515

  • The Effects of Race, Ethnicity, and Underlying Medical Diseases on Osteoporosis Are Still Unguided Territory for Internists

    • Hau Liu,
    • Paul Shekelle,
    • Amir Qaseem,
    • and Eric Orwoll
    Ann Intern Med October 7, 2008 149:515-516

  • Symptomatic Hepatitis Associated with the Use of Herbal Red Yeast Rice

    • Harry Roselle,
    • Andrew Ekatan,
    • Jausheng Tzeng,
    • Mark Sapienza,
    • and Jeffrey Kocher
    Ann Intern Med October 7, 2008 149:516-517

  • Right-Sided Native Valve Endocarditis Revealing Adult-Onset Still Disease

    • Alain Saraux,
    • Aymeric Binard,
    • Valérie Devauchelle-Pensec,
    • Yannick Jobic,
    • and Sandrine Jousse-Joulin
    Ann Intern Med October 7, 2008 149:517-519

  • Correction: Using Standarized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate

    Ann Intern Med October 7, 2008 149:519

  • Correction: Is There Enough Evidence to Support Use of N-Acetylcysteine in Contrast-Induced Nephropathy?

    Ann Intern Med October 7, 2008 149:519

  • Correction: Trial by Fire: In Memoriam

    Ann Intern Med October 7, 2008 149:519

Medical Writings: Book Notes

  • Without Your Consent: The Hijacking of American Health Care

    • Michael K. Gusmano
    Ann Intern Med October 7, 2008 149:520

  • Alternative Medicine?: A History

    • Wayne B. Jonas
    Ann Intern Med October 7, 2008 149:520

Ad Libitum

Summaries for Patients

  • Stool DNA and Occult Blood Testing to Screen for Colorectal Neoplasia

    Ann Intern Med October 7, 2008 149:I-20

  • Type of Exercise-Induced Arrhythmia on Exercise Test and Risk for Death

    Ann Intern Med October 7, 2008 149:I-22

  • Counseling during Primary Care Visits to Prevent Sexually Transmitted Infections: U.S. Preventive Services Task Force Recommendations

    Ann Intern Med October 7, 2008 149:I-36

In the Clinic

  • Obesity

    Ann Intern Med October 7, 2008 149:ITC4-1

    This issue provides a clinical overview of obesity, focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits.

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This Issue

October 7, 2008; 149 (7)
  1. Articles
  2. Improving Patient Care
  3. Review
  4. Clinical Guidelines
  5. Editorial
  6. On Being a Doctor
  7. Letters
  8. Medical Writings: Book Notes
  9. Ad Libitum
  10. Summaries for Patients
  11. In the Clinic

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