Monitoring Cholesterol Levels: Understanding Variance and Finding the Most Useful Data

  1. Paul P. Glasziou, MBBS, PhD; and
  2. Les Irwig, MBBS, PhD
  1. From University of Oxford, Oxford OX3 7LF, United Kingdom, and University of Sydney, Sydney, New South Wales 2006, Australia.

    IN RESPONSE:

    We thank Dr. Timbie for the 2 corrections. All our calculations and writing were done in mmol/L, but we added the U.S. units (mg/dL) in our revision and did this incorrectly for variances (although SDs and means are correct).

    Dr. Cayley points out that most of the statin trials have used a fixed dose (4S [Scandinavian Simvastatin Survival …

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