Risk for Death Associated with Medications for Recently Diagnosed Chronic Obstructive Pulmonary Disease

  1. Todd A. Lee, PharmD, PhD;
  2. A. Simon Pickard, PhD;
  3. David H. Au, MD, MS;
  4. Brian Bartle, MPH; and
  5. Kevin B. Weiss, MD, MPH, MS
  1. From the Hines Veterans Affairs Hospital, Hines, Illinois; Northwestern University Feinberg School of Medicine, Chicago, Illinois; University of Illinois at Chicago, Chicago, Illinois; Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington; and the American Board of Medical Specialties, Evanston, Illinois.
    1. Figure 1.
      View larger version:
      Figure 1. Study flow diagram.

      COPD = chronic obstructive pulmonary disease.

    2. Figure 2.
      View larger version:
      Figure 2. Risk for mortality associated with respiratory medications in the sensitivity analyses for each study end point.

      Bars indicate 95% CIs. CHF = chronic heart failure; ICS = inhaled corticosteroid; IPRA = ipratropium; LABA = long-acting β-agonist; SABA = short-acting β-agonist; THEO = theophylline.

    Responses to this article

    • Risk for Death Associated with Medications for Recently Diagnosed COPD
      • Tushar Shah and
      • Chandrasekar Palaniswamy, MD, Westchester Medical Center, Valhalla, NY 10595.
      Ann Intern Med published online October 26, 2009
    • Authors' Reply
      • Todd A. Lee and
      • A. Simon Pickard, David H. Au
      Ann Intern Med published online October 26, 2009
    • Biases in the study of COPD medications on mortality
      • Samy Suissa and
      • Pierre Ernst
      Ann Intern Med published online October 26, 2009
    • Risk of Death Associated with COPD Medications
      • Nicholas J Gross and
      • None
      Ann Intern Med published online October 26, 2009
    • A potential bias
      • Takeharu Koga and
      • Tomoko Kamimura, Munetsugu Nishimura
      Ann Intern Med published online October 26, 2009
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    1. Ann Intern Med September 16, 2008 vol. 149 no. 6 380-390
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