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Are Short-Term or Long-Term Recurrence Rates More Important in Breast Cancer Screening?
- Steven N. Goodman, MD, MHS, PhD;
- Luigi Marchionni, MD, PhD; and
- Antonio C. Wolff, MD
- From Johns Hopkins University School of Medicine, Baltimore, MD 21287.
IN RESPONSE:
We appreciate the points made by Dr. Rutgers and colleagues, which underscore messages of our article and the editorial by Simon (1). The authors are correct that the populations on which the 2 tests were validated differed in terms of pretreatment. They also differed by estrogen receptor status: The 70-gene test was validated on a mixed population of estrogen receptor–positive and –negative patients, whereas all of the OncotypeDX patients were estrogen receptor–positive. Although there may be …
