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Why Choose Serum Cystatin C Levels over Serum Creatinine Levels as a Serologic Marker of Kidney Function?
TO THE EDITOR:
In their recent article, Kestenbaum and colleagues (1) reported that the incidence of hypertension in individuals without evident kidney disease is associated with variations in kidney function assessed by cystatin C levels. This implicates covert kidney dysfunction in the pathogenesis of hypertension. I wish to address issues concerning surrogates of clinical disease.
The authors excluded participants with overt kidney disease, defined by reduced creatinine level–based estimated glomerular filtration rate …
