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A Case of Apical Ballooning Cardiomyopathy Associated with Duloxetine
- Benjamin R. Bergman, MD;
- Harmony R. Reynolds, MD;
- Adam H. Skolnick, MD; and
- Demetrio Castillo, MD
- From New York University School of Medicine, New York, NY 10016.
Background: Catecholamine level surges may be associated with myocardial dysfunction, as observed in cases of septic shock, subarachnoid hemorrhage, respiratory failure, and pheochromocytoma (1, 2). Selective serotonin reuptake inhibitors have catecholaminergic activity but generally little cardiovascular toxicity. Duloxetine, a combined norepinephrine and selective serotonin reuptake inhibitor, has not been reported to have any major cardiovascular toxicity.
Objective: To report a case of transient apical ballooning cardiomyopathy associated with duloxetine use.
Case Report: A 60-year-old Hispanic woman presented with 5 days of dizzy spells and 1 day of chest discomfort. Electrocardiography showed ST-segment elevations and T-wave inversions, and serum troponin I level was 3.0 µg/L …
