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Is There Enough Evidence to Support Use of N-Acetylcysteine in Contrast-Induced Nephropathy?
- Giuseppe Ferrante, MD;
- Didier Locca, MD; and
- Peter Barlis, MD
- From Catholic University of the Sacred Heart, Rome 00168, Italy; Royal Brompton Hospital, London SW36NP, United Kingdom; and Northern Hospital, Epping, Victoria 3076, Australia.
TO THE EDITOR:
We read with interest the meta-analysis by Kelly and colleagues (1), in which the authors assessed the effectiveness of several drugs, including N-acetylcysteine and theophylline, in preventing contrast-induced nephropathy. They assessed a total of 41 studies and concluded that N-acetylcysteine is the most effective agent for preventing contrast-induced nephropathy (1). The authors should be commended in undertaking such a comprehensive review of the literature. However, several issues, particularly with the methods adopted in the meta-analysis, need …
