Is There Enough Evidence to Support Use of N-Acetylcysteine in Contrast-Induced Nephropathy?

  1. Hariprasad Trivedi, MD
  1. From Medical College of Wisconsin, Milwaukee, WI 53226.

    TO THE EDITOR:

    I would like to applaud Kelly and colleagues for their exhaustive meta-analysis (1), and I have some comments about their analysis.

    First, exactly how many studies involving N-acetylcysteine were included in the meta-analysis? The number of N-acetylcysteine studies in Figure 1 differs from the numbers listed in the Table and Figure 2. Why were 4 studies excluded after they were deemed to have satisfied inclusion criteria? Second, the paper cited as a study involving furosemide and mannitol (Table) …

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