Comparative Benefits and Harms of Second-Generation Antidepressants: Background Paper for the American College of Physicians

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   Figure 1. Study flow diagram.

   The number of included articles differs from the number of included studies because some studies have multiple publications.
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   Figure 2. . Relative benefit of response comparing selective serotonin reuptake inhibitors (SSRIs) with other SSRIs

   All estimates are based on network meta-analyses except for those marked with an asterisk or a dagger.

   * Based on meta-analysis of head-to-head trials.

   † Based on indirect comparisons with meta-regression.
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   Figure 3. ). Relative benefit of response comparing selective serotonin reuptake inhibitors (SSRIs) with selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) and SSRIs with serotonin and norepinephrine reuptake inhibitors (SNRIs

   All estimates are based on network meta-analyses except for those marked with an asterisk or a dagger.

   * Based on meta-analysis of head-to-head trials.

   † Based on indirect comparisons with meta-regression.
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   Figure 4. Relative benefit of response comparing selective serotonin reuptake inhibitors (SSRIs), selective serotonin and norepinephrine reuptake inhibitors (SSNRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and other second-generation antidepressants (ADs) with other second-generation ADs.

   All estimates are based on network meta-analyses except for those marked with an asterisk.* Based on meta-analysis of head-to-head trials.