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Comparative Benefits and Harms of Second-Generation Antidepressants: Background Paper for the American College of Physicians
- Gerald Gartlehner, MD, MPH;
- Bradley N. Gaynes, MD, MPH;
- Richard A. Hansen, PhD, RPh;
- Patricia Thieda, MA;
- Angela DeVeaugh-Geiss, MS;
- Erin E. Krebs, MD, MPH;
- Charity G. Moore, PhD, MSPH;
- Laura Morgan, MA; and
- Kathleen N. Lohr, PhD
- From Danube University, Krems, Austria; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Indiana University School of Medicine, Roudebush Veterans Affairs Medical Center, and Regenstrief Institute, Indianapolis, Indiana; University of Pittsburgh, Pittsburgh, Pennsylvania; and RTI International, Research Triangle Park, North Carolina.
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Figure 1. Study flow diagram.The number of included articles differs from the number of included studies because some studies have multiple publications.
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Figure 2. . Relative benefit of response comparing selective serotonin reuptake inhibitors (SSRIs) with other SSRIsAll estimates are based on network meta-analyses except for those marked with an asterisk or a dagger.
* Based on meta-analysis of head-to-head trials.
† Based on indirect comparisons with meta-regression.
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Figure 3. ). Relative benefit of response comparing selective serotonin reuptake inhibitors (SSRIs) with selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) and SSRIs with serotonin and norepinephrine reuptake inhibitors (SNRIsAll estimates are based on network meta-analyses except for those marked with an asterisk or a dagger.
* Based on meta-analysis of head-to-head trials.
† Based on indirect comparisons with meta-regression.
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Figure 4. Relative benefit of response comparing selective serotonin reuptake inhibitors (SSRIs), selective serotonin and norepinephrine reuptake inhibitors (SSNRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and other second-generation antidepressants (ADs) with other second-generation ADs.All estimates are based on network meta-analyses except for those marked with an asterisk.* Based on meta-analysis of head-to-head trials.
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