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Memantine-Induced Hepatitis with Cholestasis in a Very Elderly Patient
- Nicola Ferrara, MD;
- Graziamaria Corbi, MD, PhD;
- Annalisa Capuano, MD;
- Amelia Filippelli, MD, PhD; and
- Francesco Rossi, MD
- From University of Molese, Campobasso 86100, Italy, and Second University of Naples, Naples 80138, Italy.
Background: Memantine, recently approved in Europe and the United States for treating dementia, has been shown to reduce clinical deterioration in moderate-to-severe Alzheimer disease and in vascular dementia (1). To our knowledge, there are no reports of hepatotoxicity during treatment with memantine.
Objective: To describe a case of memantine-induced hepatotoxicity in a very elderly patient with mixed, moderate dementia and behavior disorders.
Case Report: A 92-year-old white woman with hypertension and heart failure (New York Heart Association class II to III) had mixed, moderate dementia and behavior disorders. She was on a home care program and was taking digoxin, 0.125 mg/d; lisinopril, 5 mg/d; tiapride, 50 mg/d; alprazolam, 0.25 mg/d; and promazine, 10 mg/d. The patient …
