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What Is the Best End Point for Hepatitis B Treatment?
- Ching-Lung Lai, MD; and
- Man-Fung Yuen, MD, PhD
- From the University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
TO THE EDITOR:
We write in response to the editorial by Degertekin and Lok (1), which addressed our article on standard treatment criteria and end points for hepatitis B (2). Degertekin and Lok state that “[a]lthough HBV [hepatitis B virus] replication after HBeAg [hepatitis B e antigen] seroconversion can be reactivated … an occurrence of 30% over 10 years does not justify continuing treatment for all patients” (1). A 30% occurrence rate is very high. The risk for myocardial infarction with hypercholesterolemia in a placebo-controlled trial …
