Nonbenzodiazepine Hypnotic Use and Cases of “Sleep Driving”

  1. Mary Ross Southworth, PharmD;
  2. Cindy Kortepeter, PharmD; and
  3. Alice Hughes, MD
  1. From U.S. Food and Drug Administration, Silver Spring, MD 20993.

    Background: “Sleep driving” is a complex, sleep-related behavior described as rising out of bed and driving a vehicle while not fully awake or during an apparent state of sleep, often with no memory of the event afterward. This phenomenon has been reported rarely in the literature (1, 2) and in conjunction with other somnambulistic behavior, such as homicidal somnambulism and nocturnal violence.

    Objective: To summarize cases of sleep driving associated with the use of the nonbenzodiazepine hypnotics reported to the U.S. Food and Drug Administration (FDA) Adverse Events Reporting System.

    Methods: On 1 March 2006, we searched the FDA Adverse Events Reporting System …

    This 100-word excerpt has been provided in the absence of an abstract.

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