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Biological Significance of Anti–Cyclic Citrullinated Peptide Antibody in Rheumatoid Arthritis
- Ronenn Roubenoff, MD, MHS;
- Evan Beckman, MD;
- Michael Weinblatt, MD;
- Nancy Shadick, MD, MPH; and
- Peter K. Gregersen, MD
- From Biogen Idec Immunology Research & Development, Cambridge, MA 02142; Brigham & Women's Hospital, Boston, MA 02115; and Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, NY 11030.
TO THE EDITOR:
We read with great interest the thorough meta-analysis and review by Nishimura and colleagues (1) on the diagnostic accuracy of anti–cyclic citrullinated peptide (CCP) antibody in rheumatoid arthritis (RA). The authors conclude that although anti-CCP antibodies are more specific than rheumatoid factor, their sensitivity is only 67%. However, we believe that anti-CCP may …
