Analyzing the Results of the Treating to New Targets Study
- Vera Bittner, MD;
- David Herrington, MD; and
- Nanette Wenger, MD
- From University of Alabama at Birmingham, Birmingham, AL 35294; Wake Forest University School of Medicine, Winston-Salem, NC 27157; and Emory University School of Medicine, Atlanta, GA 30303.
IN RESPONSE:
We thank Dr. Alter, Dr. Mascitelli and Mr. Vos, and Dr. Goldstein for their careful reviews of our paper. Treatment effect was qualitatively similar in participants age 35 to 64 years and age 65 to 75 years, providing some reassurance that age does not importantly modify treatment effect. Because treatment duration was 4.9 years, some follow-up is derived from participants older than 75 years. Nonetheless, we agree that the TNT study results do not provide definitive efficacy or safety information for the 5% of the U.S. population older than 75 years. A manuscript comparing outcomes by …
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