RSS Feeds
Agranulocytosis Induced by Nonchemotherapy Drugs
- Luisa Ibáñez, PhD, MD;
- Xavier Vidal, PhD, MD; and
- Joan-Ramon Laporte, PhD, MD
- From Clinical Pharmacology Service, Vall d'Hebron Hospital, Universitat Autònoma, Fundació Institut Català de Farmacología, 08035 Barcelona, Spain.
TO THE EDITOR:
In their recent interesting article, Andersohn and colleagues (1) present a systematic review of case reports of drugs definitely or probably related to agranulocytosis. However, the definition of a plausible time relationship to drug administration includes the onset of acute agranulocytosis occurring within 1 month after treatment withdrawal. This definition could lead to a misclassification of drug causality because agranulocytosis is mainly an immunologic disorder, and a drug is unlikely to induce the disorder if it or its metabolites are not present in the …
