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Systematic Review: Hydroxyurea for the Treatment of Adults with Sickle Cell Disease
- Sophie Lanzkron, MD;
- John J. Strouse, MD;
- Renee Wilson, MSc;
- Mary Catherine Beach, MD, MPH;
- Carlton Haywood, MA;
- HaeSong Park, MD, MPH;
- Catherine Witkop, MD, MPH;
- Eric B. Bass, MD, MPH; and
- Jodi B. Segal, MD, MPH
- From the School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
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View larger version:Figure. Study flow diagram.RCT = randomized, controlled trial; SCD = sickle cell disease. *The evidence report provides details of the search strategies (7). †The reasons for exclusion exceed the total number of studies because reviewers could enter multiple reasons for exclusion. ‡89 studies were not included in this review because they included children or infants only or examined barriers only. Toxicity and efficacy studies in SCD overlap.
