Review of Comparative Effectiveness of Treatments to Prevent Fractures

  1. Lionel S. Lim, MD, MPH
  1. From Griffin Hospital, Derby, CT 06418.

    TO THE EDITOR:

    MacLean and colleagues did not mention musculoskeletal adverse effects associated with bisphosphonates in their review of osteoporosis treatments (1). Although most adverse effects are gastrointestinal, bisphosphonate use may also induce musculoskeletal side effects. Postmarketing reports describe severe disabling and incapacitating …

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