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Possible Benefit to Survival from Early Invasive Strategies in Patients with Acute Coronary Syndromes
- Rehan Qayyum, MD;
- Jurga Adomaityte, MD; and
- M. Rizwan Khalid, MD
- From Johns Hopkins School of Medicine, Baltimore, MD 21287, and New York Hospital Queens, Flushing, NY 11355.
IN RESPONSE:
We appreciate Drs. Kumbhani and Bavry's interest in our systematic review. They suggest that excluding 3 trials (TIMI IIIB, VANQWISH, and MATE) that were performed before the current era of glycoprotein IIb/IIIa and coronary stenting would yield different results. When we excluded these 3 trials from meta-analyses, our results did not change (relative risk for death, 0.88 [95% CI, 0.72 to 1.07]; for nonfatal myocardial infarction, 0.82 [CI, 0.57 …
