New Tests for the Diagnosis of Latent Tuberculosis Infection

  1. Dick Menzies, MD, MSc; and
  2. Madhukar Pai, MD, PhD
  1. From Montreal Chest Institute, McGill University, Montréal, Québec H2X 2P4, Canada.

    IN RESPONSE:

    We agree with Drs. Kunst and Khan that the lack of a proper gold standard is a fundamental problem of all cross-sectional studies of diagnostic tests for latent tuberculosis infection. We state this problem explicitly several times in our paper. We believe that longitudinal studies following cohorts of persons with positive or negative test results will be most valuable, because the later development of active tuberculosis is the only certain indicator of the presence of …

    This 100-word excerpt has been provided in the absence of an abstract.

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