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Weight-Based Low-Molecular-Weight Heparin versus Weight-Based Intravenous Unfractionated Heparin
- Jodi B. Segal, MD, MPH;
- Michael B. Streiff, MD; and
- Eric B. Bass, MD, MPH
IN RESPONSE:
We appreciate the analyses by Dr. Umscheid and colleagues of a subgroup of the studies that were included in the systematic reviews we identified. These analyses confirm that there is little difference in outcomes (both efficacy and safety outcomes) between weight-based UFH and weight-based LMWH. We expect that practice patterns have changed since the publication of most of these trials; it is usual practice in most institutions to use a weight-based nomogram for intravenous heparin dosing. We are pleased that Dr. Umscheid and colleagues' analyses support the recommendations in the guidelines in this current era of weight-based dosing of both UFH and LMWH.
Jodi B. Segal, MD, MPH
Michael B. Streiff, MD
Eric B. Bass, MD, MPH
Johns Hopkins University School of Medicine
Baltimore, MD 21205
Article and Author Information
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Potential Financial Conflicts of Interest: None disclosed.
