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Weight-Based Low-Molecular-Weight Heparin versus Weight-Based Intravenous Unfractionated Heparin
- Craig A. Umscheid, MD, MSCE;
- Rajender Agarwal, MPH; and
- Gene Gibson, PharmD
- From the University of Pennsylvania Health System Center for Evidence-Based Practice and Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
TO THE EDITOR:
In regard to the systematic review evaluating the management of venous thromboembolism (VTE) by Segal and colleagues (1), we are concerned that the analyses comparing the efficacy and safety of low-molecular-weight heparin (LMWH) with unfractionated heparin (UFH) are biased against UFH. In 1993, Raschke and colleagues (2) demonstrated the superior efficacy and safety of the weight-based UFH dosing nomogram compared with …
