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Chondroitin for Osteoarthritis of the Knee or Hip
- Sven Trelle, MD;
- Stephan Reichenbach, MD; and
- Peter Jüni, MD
- From University of Bern, 3012 Bern, Switzerland.
IN RESPONSE:
As correctly pointed out by Dr. Goldberg and colleagues, our meta-analysis was hampered by the limited quality of included trials and the heterogeneity of their results. Therefore, the interpretation of the meta-analysis of all trials was difficult and the investigation of potential sources of heterogeneity mandatory (1). The restriction of the analysis to large-scale, high-quality trials covering 40% of patients was not based on subjective judgment, but on results from stratified analyses and corresponding interaction tests. All explored factors were prespecified before initiating our systematic review. The 3 factors associated with treatment effects—concealment of allocation, intention-to-treat analysis, and …
