Tiotropium in Combination with Placebo, Salmeterol, or Fluticasone–Salmeterol for Chronic Obstructive Pulmonary Disease: Possible Confounding Effect of Treatment Withdrawal?

  1. Shawn D. Aaron, MD
  1. From the Ottawa Health Research Institute, Ottawa, Ontario K1H 8L6, Canada.

    IN RESPONSE:

    We thank Dr. Brown for his comments. He is correct that many patients randomly assigned into our clinical trial were already taking inhaled corticosteroids and/or LABAs at enrollment and that withdrawal effects may have played …

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    1. Ann Intern Med December 18, 2007 vol. 147 no. 12 882-883
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