
The size of each box is proportional to the sample size of the trial. Bars represent 95% CIs. The I2 statistic was 40. All studies that reported comparative effectiveness data for patients with diabetes were included in this analysis, not just studies that reported comparative outcomes for patients with and without diabetes. Hazard ratios from the German Angioplasty Bypass Surgery Investigation for death after PCI or CABG were reported to not differ between patients with or without diabetes; however, these data were not shown. AWESOME = Angina with Extremely Serious Operative Mortality Evaluation; BARI = Bypass Angioplasty Revascularization Investigation; CABG = coronary artery bypass grafting; EAST = Emory Angioplasty versus Surgery Trial; ERACI = Argentine randomized trial of percutaneous transluminal coronary angioplasty versus coronary artery bypass surgery in multivessel disease; MASS = Medicine, Angioplasty, or Surgery Study; PCI = percutaneous coronary intervention; RITA = Randomized Intervention Treatment of Angina.