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Blood Products for Spanish Influenza: A Future H5N1 Treatment?
- Thomas C. Luke, MD, MTMH, MA; and
- Stephen L. Hoffman, MD, DTMH
- From the Bureau of Medicine and Surgery, U.S. Navy, Washington, DC 20372-3000.
IN RESPONSE:
We agree with Drs. Logtenberg and Bilo that the possible benefit of convalescent blood products, including plasma, for treating Spanish influenza pneumonia may not have been entirely due to the presence of neutralizing antibodies.
Plasma is a complex mixture of immunoglobulins, coagulation factors, cytokines, and other immunologically and physiologically active molecules. It …
