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Lack of Evidence for Recommended Low-Density Lipoprotein Cholesterol Treatment Targets
TO THE EDITOR:
Hayward and colleagues (1) rightly point out the extreme weakness of ecological comparisons among statin trials. Their concern is justified by the lack of dose response between the degree of cholesterol lowering and the clinical (2, 3) or angiographic (4) outcome found in the trials where dose response was calculated by using …
