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Reducing the Incidence of High-Altitude Pulmonary Edema
- Marco Maggiorini, MD; and
- Heimo Mairbäurl, PhD
- From University Hospital Zürich, Zürich, Switzerland, and the University of Heidelberg, Heidelberg, Germany.
IN RESPONSE:
We thank Mr. Pun and Dr. Ghimire and Dr. Basnyat for their interest and comments on our recent publication. When we designed and performed our study, Richalet and colleagues (1) and Aldashev and colleagues (2) had not yet published their work on sildenafil, which both showed that sildenafil decreases hypoxic pulmonary hypertension. Sildenafil must be taken in rather brief intervals because of its short half-life of 4 to 5 hours. Because we tested the effectiveness of 2 drugs in our study, …
