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Adiposity of the Heart
- Lidia S. Szczepaniak, PhD;
- Jonathan M. McGavock, PhD;
- Ronald G. Victor, MD; and
- Roger H. Unger, MD
- From University of Texas Southwestern Medical Center, Dallas, TX 75390-8899.
IN RESPONSE:
Dr. Kanna's suggestion of a relationship between lipid overload of cardiomyocytes and abnormal cardiac late potentials may provide a valuable new dimension in evaluation of the obese heart. It will be of interest to learn whether measures that reverse cardiac steatosis overturn the abnormal late potentials. The role of elevated free fatty acids in the development of cardiac arrhythmias has been explored by others (1–3); this may be a primary cause of abnormal late potentials in individuals with type 2 diabetes or the metabolic syndrome.
Dr. Leslie points out that Austin Flint described fatty heart disease …
