Adiposity of the Heart
TO THE EDITOR:
The review by McGavock and colleagues (1) probably incorrectly states that “overexpression of long-chain acyl-CoA synthetase, a key enzyme involved in triglyceride synthesis, produces an example of cardiac-restricted steatosis.” Long-chain acyl-CoA synthetase is an initial enzyme that is involved in fatty-acid β-oxidation and, after subsequent dehydrogenase and hydrolase reactions, …
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