Narrative Review: Lack of Evidence for Recommended Low-Density Lipoprotein Treatment Targets: A Solvable Problem

Top. Event rate assuming a single association between low-density lipoprotein (LDL) cholesterol and outcome. Bottom. The LDL–outcome associations found within each study. 4S= Scandinavian Simvastatin Survival Study; CARE= Cholesterol and Recurrent Events Study; HPS= Heart Protection Study; LIPID= Long-Term Intervention with Pravastatin in Ischaemic Disease Study; TNT= Treating to New Targets Study. To convert LDL cholesterol values to mmol/L, multiply by 0.02586.