Severe Hepatotoxicity of Telithromycin

IN RESPONSE:

In case 1, the patient started to notice dark urine on day 2 of treatment with telithromycin. When his wife noted continued symptoms on day 3, the patient decided to stop taking the medication. It was a week later, when the patient presented to his physician, that the laboratory tests were performed and abnormalities were noted.

With respect to case 3, I would say that the levels of acetaminophen, salicylate, and ethylene glycol were negative, which was expected based on the history given by the patient.