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Octreotide-Induced Manic Episodes in a Patient with Acromegaly
- José-Manuel Fernández-Real, MD, PhD;
- Mónica Recasens, MD; and
- Wifredo Ricart, MD
- From Hospital de Girona Doctor Josep Trueta, 17007 Girona, Spain.
Background: Psychotic reactions have been well documented in patients receiving therapy with low doses of bromocriptine (1) and other dopaminergic agonists. Dopamine stimulates somatostatin release. In animals, somatostatin influences a wide spectrum of behavioral functions, including learning, regulation of slow-wave sleep, and locomotor activity. These functions are often altered in patients with manic episodes (2), and some alterations have also been described in humans after administration of octreotide (3).
Objective: To describe a patient with acromegaly in whom the administration of the long-acting somatostatin analogue octreotide precipitated a manic episode …
