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Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients
- Andre C. Kalil, MD; and
- Julie Stoner, PhD
- From the University of Nebraska, Nebraska Medical Center, Omaha, NE 68198-5400.
IN RESPONSE:
We appreciate Dr. Singh's and Ms. Wagener's comments but must address several points of disagreement. First, we do not agree that our conclusions may be misleading. As discussed in our paper, trial design limitations, duration of follow-up, and prophylaxis were thoroughly evaluated by sensitivity analyses, and the conclusions of our meta-analysis remained unchanged.
Second, Dr. Singh and Ms. Wagener do not feel that the studies by Hibberd (1) and Conti (2) and colleagues can truly be considered preemptive therapy. Of interest, both of these studies have the words “preemptive ganciclovir therapy” in their titles. After considering …
