Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients

  1. Nina Singh, MD; and
  2. Marilyn M. Wagener, MPH
  1. From the University of Pittsburgh and VA Medical Center, Pittsburgh, PA 15240.

    TO THE EDITOR:

    The meta-analysis by Kalil and colleagues (1) examining universal prophylaxis and preemptive therapy for cytomegalovirus (CMV) organ disease addresses an important issue. However, the conclusions may be potentially misleading because of significant limitations of the included studies, variability in the duration of prophylaxis and the length of follow-up in the published studies, and the selection of trials for the meta-analysis. The studies by Conti (2) and Hibberd (3) and colleagues cannot truly be considered to examine preemptive therapy. Prophylactic use of an antiviral agent in patients receiving antilymphocytic …

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    • Article:Meta-Analysis: The Efficacy of Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients
      • Andre C. Kalil,
      • Josh Levitsky,
      • Elizabeth Lyden,
      • Julie Stoner,
      • and Alison G. Freifeld
      Ann Intern Med December 20, 2005 143:870-880
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    1. Ann Intern Med March 21, 2006 vol. 144 no. 6 456-457
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