Table of Contents

February 7, 2006; 144 (3)

Articles

  • Appropriateness of Diagnostic Management and Outcomes of Suspected Pulmonary Embolism

    • Pierre-Marie Roy,
    • Guy Meyer,
    • Bruno Vielle,
    • Catherine Le Gall,
    • Franck Verschuren,
    • Françoise Carpentier,
    • Philippe Leveau,
    • Alain Furber,
    • and for the EMDEPU Study Group*
    Ann Intern Med February 7, 2006 144:157-164

    The authors compared the diagnostic management of suspected pulmonary embolism (PE) with evidence-based criteria. The decision to rule in PE was in accord with established criteria in 92% of 429 patients. The decision to rule out PE was in accord with the criteria in only 43% of 1100 patients. In 39 of the 44 patients who had venous thromboembolism during follow-up, the physician had not used appropriate criteria to rule out PE.

  • Prediction of Pulmonary Embolism in the Emergency Department: The Revised Geneva Score

    • Grégoire Le Gal,
    • Marc Righini,
    • Pierre-Marie Roy,
    • Olivier Sanchez,
    • Drahomir Aujesky,
    • Henri Bounameaux,
    • and Arnaud Perrier
    Ann Intern Med February 7, 2006 144:165-171

    To improve diagnosis of pulmonary embolism (PE), the authors constructed a simple scoring system to estimate the probability of PE. Clinical predictors included age, previous venous thromboembolism, recent surgery or fracture, active cancer, unilateral lower-limb pain, hemoptysis, heart rate, a tender deep vein, and unilateral leg edema. In the validation set, the prevalence of PE was 8%, 29%, and 74% in the low-, intermediate-, and high-probability categories, respectively.

  • Cardiovascular Outcomes in High-Risk Hypertensive Patients Stratified by Baseline Glomerular Filtration Rate

    • Mahboob Rahman,
    • Sara Pressel,
    • Barry R. Davis,
    • Chuke Nwachuku,
    • Jackson T. Wright, Jr.,
    • Paul K. Whelton,
    • Joshua Barzilay,
    • Vecihi Batuman,
    • John H. Eckfeldt,
    • Michael A. Farber,
    • Stanley Franklin,
    • Mario Henriquez,
    • Nelson Kopyt,
    • Gail T. Louis,
    • Mohammad Saklayen,
    • Carole Stanford,
    • Candace Walworth,
    • Harry Ward,
    • Thomas Wiegmann,
    • and for the ALLHAT Collaborative Research Group*
    Ann Intern Med February 7, 2006 144:172-180

    In this post hoc analysis of a subgroup of the Anti-hypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), patients with hypertension and chronic kidney disease were more likely to develop coronary heart disease (CHD) than to develop end-stage renal disease. A low glomerular filtration rate independently predicted CHD. Neither amlodipine nor lisinopril was superior to chlorthalidone in preventing cardiovascular disease outcomes or renal failure.

  • Brief Communication: Successful Treatment of Pure Red-Cell Aplasia with an Anti–Interleukin-2 Receptor Antibody (Daclizumab)

    • Elaine M. Sloand,
    • Phillip Scheinberg,
    • Jaroslaw Maciejewski,
    • and Neal S. Young
    Ann Intern Med February 7, 2006 144:181-185

    Pure red-cell aplasia is an autoimmune disease. The authors treated 15 affected patients with 5 weekly injections of a humanized monoclonal antibody to the interleukin-2 receptor (daclizumab). Six patients (40%) responded to treatment. All responders became transfusion-independent and achieved normal or near-normal hemoglobin values and normal reticulocyte counts. In this small study, daclizumab did not have adverse effects.

Academia and Clinic

  • Translating Clinical Research into Clinical Practice: Impact of Using Prediction Rules To Make Decisions

    • Brendan M. Reilly and
    • Arthur T. Evans
    Ann Intern Med February 7, 2006 144:201-209

    The purpose of clinical prediction rules is to help physicians use a patient's clinical findings to estimate disease probability and in turn to tailor the choice and interpretation of diagnostic tests to the patient. Without formal impact analysis, clinicians cannot know whether a rule will be beneficial or harmful. This paper reviews standards of evidence for developing and evaluating the potential clinical impact of using a clinical prediction rule in practice.

Updates

  • Update in Hospital Medicine

    • Jeffrey G. Wiese and
    • Russell L. Holman
    Ann Intern Med February 7, 2006 144:195-200

    This Update summarizes important papers from 2004 for physicians with active inpatient practices. It covers hospitalist comanagement, atrial fibrillation, chronic heart failure, pulmonary embolism, catheter-related bloodstream infections, nephropathy, fluid resuscitation, antiplatelet therapy, adverse events following hospital discharge, and dementia.

Review

  • Nephrogenic Diabetes Insipidus

    • Jeff M. Sands and
    • Daniel G. Bichet
    Ann Intern Med February 7, 2006 144:186-194

    Nephrogenic diabetes insipidus (NDI) is a relatively rare disorder in which the kidney is unresponsive to the water-retaining action of vasopressin. With early diagnosis and therapy, children with NDI develop without mental retardation and survive into adulthood. Adults develop acquired NDI most commonly because of lithium therapy for bipolar disorders. Treatment options are limited.

Editorials

  • Better Care for Patients with Suspected Pulmonary Embolism

    • Harold C. Sox
    Ann Intern Med February 7, 2006 144:210-212

    This issue contains 2 articles about the management of suspected pulmonary embolism (PE). One shows that physicians frequently fail to use evidence-based diagnostic guidelines, especially when interpreting negative test results. The companion article describes a clinical prediction rule for classifying patients with suspected PE into low-, medium-, and high-risk categories. These studies are representative of the very high-quality body of evidence to guide decision making for suspected PE. We have a wide gap between our abundant knowledge and its application. Computer-based decision support for diagnosing suspected PE is an idea whose time is at hand, if not long overdue.

  • Which Antihypertensive Agents in Chronic Kidney Disease?

    • Andrew S. Levey and
    • Katrin Uhlig
    Ann Intern Med February 7, 2006 144:213-215

    In this issue, Rahman and colleagues report cardiovascular disease in chronic kidney disease from the randomized study known as ALLHAT. They had previously reported outcomes of kidney disease in this group. Because so many ALLHAT participants had chronic kidney disease, it is the largest study of hypertension treatment in patients with this disorder. This editorial compares ALLHAT results with previous studies of antihypertensive treatment in patients with chronic kidney disease.

On Being a Doctor

  • Transport

    • Dean Gianakos
    Ann Intern Med February 7, 2006 144:216

    I love to see the last patient of the day. There are no time pressures to see other patients. I am not distracted by phone calls, knocks on the door, or overhead pages. The work of the day is almost done, and I can sit back and give the patient my full attention.

  • The Middle Time

    • Michael Aylward
    Ann Intern Med February 7, 2006 144:217

    The people on the road just do not understand the general need to get out of my way. Frustration and resentment are not too far under my skin after 30-odd hours of wakefulness and decision making. Everyone else is coming home from a day's work—I've got 2 days under my belt. Doesn't that give me some kind of priority?

Letters

  • Acute Exacerbations in Idiopathic Pulmonary Fibrosis

    • Seamus P. Crowley,
    • Peter Kelly,
    • and Jim J. Egan
    Ann Intern Med February 7, 2006 144:218

  • Acute Exacerbations in Idiopathic Pulmonary Fibrosis

    • Fernando J. Martinez
    Ann Intern Med February 7, 2006 144:218-219

  • Quality of Care for Vulnerable Older Patients

    • Stephanie L. Garrett,
    • James G. O'Brien,
    • and Toni P. Miles
    Ann Intern Med February 7, 2006 144:219

  • Quality of Care for Vulnerable Older Patients

    • Takahiro Higashi,
    • Neil Wenger,
    • and Paul Shekelle
    Ann Intern Med February 7, 2006 144:219-220

  • The Pitfalls of Introducing Electronic Medical Records

    • Mark Faron,
    • Thomas Hale,
    • and Linda Jesberg
    Ann Intern Med February 7, 2006 144:220

  • Presentation of Diagnostic Test Accuracy

    • Mike Broce and
    • Bernardo Reyes
    Ann Intern Med February 7, 2006 144:220-221

  • Presentation of Diagnostic Test Accuracy

    • Daniel J. Brotman
    Ann Intern Med February 7, 2006 144:221

  • Presentation of Diagnostic Test Accuracy

    • Milo A. Puhan,
    • Johann Steurer,
    • and Gerben ter Riet
    Ann Intern Med February 7, 2006 144:221-222

  • Thyrotoxicosis as a Risk Factor for Pulmonary Arterial Hypertension

    • Ronald C. Ma and
    • Chun Chung Chow
    Ann Intern Med February 7, 2006 144:222

  • Thyrotoxicosis as a Risk Factor for Pulmonary Arterial Hypertension

    • Lewis J. Rubin and
    • David B. Badesch
    Ann Intern Med February 7, 2006 144:222-223

  • Liver Transplantation in HIV-Seropositive Individuals

    • Margaret V. Ragni,
    • Steven H. Belle,
    • KyungAh Im,
    • John Fung,
    • Guy Neff,
    • Michelle Roland,
    • Peter Stock,
    • Nigel Heaton,
    • and Abhi Humar
    Ann Intern Med February 7, 2006 144:223

  • Liver Transplantation in HIV-Seropositive Individuals

    • Ronald L. Koretz and
    • Timothy O. Lipman
    Ann Intern Med February 7, 2006 144:223-224

  • Savings from Canadian Internet Pharmacies Are Limited

    • Michael Rothberg
    Ann Intern Med February 7, 2006 144:224

  • Savings from Canadian Internet Pharmacies Are Limited

    • Mark J. Eisenberg,
    • Rafael Firszt,
    • and Bradley Quon
    Ann Intern Med February 7, 2006 144:224-225

  • Undisclosed Conflicts of Interest

    • Daniel M. Musher
    Ann Intern Med February 7, 2006 144:225

  • Undisclosed Conflicts of Interest

    • Peter H. Stone
    Ann Intern Med February 7, 2006 144:225-226

  • Regression of Cutaneous and Gastrointestinal Telangiectasia with Sirolimus and Aspirin in a Patient with Hereditary Hemorrhagic Telangiectasia

    • Vivian C. McAlister
    Ann Intern Med February 7, 2006 144:226-227

  • Correction: Update in Cardiology

    Ann Intern Med February 7, 2006 144:227

Medical Writings: Book Notes

  • An Introduction to Clinical Emergency Medicine: Guide for Practitioners in the Emergency Department

    • Richard O. Cummins
    Ann Intern Med February 7, 2006 144:228

  • Handbook of Peripheral Neuropathy

    • Michael Benatar
    Ann Intern Med February 7, 2006 144:228

Medical Notices

  • Medical Notices

    Ann Intern Med February 7, 2006 144:0

Summaries for Patients

  • Emergency Room Management of Patients with Suspected Pulmonary Embolism

    Ann Intern Med February 7, 2006 144:I-24

  • Do the Effects of Blood Pressure Drugs Differ by Kidney Function?

    Ann Intern Med February 7, 2006 144:I-33
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This Issue

February 7, 2006; 144 (3)
  1. Articles
  2. Academia and Clinic
  3. Updates
  4. Review
  5. Editorials
  6. On Being a Doctor
  7. Letters
  8. Medical Writings: Book Notes
  9. Medical Notices
  10. Summaries for Patients

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