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Inhaled Treprostinil for Treatment of Chronic Pulmonary Arterial Hypertension
- Robert Voswinckel, MD;
- Hossein A. Ghofrani, MD;
- Friedrich Grimminger, MD;
- Werner Seeger, MD; and
- Horst Olschewski, MD
- From the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria.
TO THE EDITOR:
Background: Treprostinil is a stable prostacyclin analogue that is approved for the treatment of pulmonary arterial hypertension when administered by continuous subcutaneous infusion (1). Inhalation of the stable prostacyclin analogue iloprost has proven clinical efficacy in patients with pulmonary hypertension in a randomized, controlled trial (2).
Objective: To characterize the effects of inhaled treprostinil with special regard to safety, tolerability, and efficacy in patients with severe pulmonary arterial hypertension.
Methods and Findings: Three patients with severe pulmonary hypertension underwent catheterization of the right heart …
This 100-word excerpt has been provided in the absence of an abstract.
