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Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease with Tiotropium
TO THE EDITOR:
Niewoehner and colleagues'report (1) is concerning because it does not satisfy either of the 2 basic moral considerations that govern the ethics of clinical trial design (2).
The first consideration dictates that the research must strive to answer clinically important questions by using scientifically valid methods. Inhaled ipratropium can be considered a standard of care for patients with …
