Transmission of Hepatitis C Virus to Several Organ and Tissue Recipients from an Antibody-Negative Donor
- Barna D. Tugwell, MD;
- Priti R. Patel, MD, MPH;
- Ian T. Williams, PhD, MS;
- Katrina Hedberg, MD, MPH;
- Feng Chai, PhD;
- Omana V. Nainan, PhD;
- Ann R. Thomas, MD, MPH;
- Judith E. Woll, MD;
- Beth P. Bell, MD, MPH; and
- Paul R. Cieslak, MD
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From the Centers for Disease Control and Prevention, Atlanta, Georgia; Oregon Department of Human Services, Portland, Oregon;
and Community Blood Center, Community Tissue Services, and Wright State University School of Medicine, Dayton, Ohio.
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Figure 1. Dates of transplantation for 2 recipients were unknown. Hepatitis C virus infection was diagnosed in 3 recipients
in September, October, and November 2001. These recipients had undergone transplantation in February 2001, October 2000, and
April 2001, respectively. Transplantation of grafts from a donor with hepatitis C virus (HCV) infection, by month of transplantation and case status
(n= 38), United States, 2000–2002.
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Figure 2. Each branch represents a different viral sequence, and small distances between branches suggest genetic relatedness.
Sequences belonging to each NHANES III participant and a recipient known to have been infected before transplantation are
marked by separate shaded regions. The size of each shaded region represents the genetic diversity of quasi-species from that
specimen or group of specimens. Isolates belonging to the donor and 8 case-patients are clustered together. Unrooted phylogenetic tree of hypervariable region sequences of graft donor, graft recipients, and selected Third National
Health and Nutrition Examination Survey (NHANES III) participants, United States, 2000–2002.
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Ann Intern Med
November 1, 2005
vol. 143
no. 9
648-654
RSS Feeds
View larger version:Figure 1. Dates of transplantation for 2 recipients were unknown. Hepatitis C virus infection was diagnosed in 3 recipients in September, October, and November 2001. These recipients had undergone transplantation in February 2001, October 2000, and April 2001, respectively. Transplantation of grafts from a donor with hepatitis C virus (HCV) infection, by month of transplantation and case status (n= 38), United States, 2000–2002.
View larger version:Figure 2. Each branch represents a different viral sequence, and small distances between branches suggest genetic relatedness. Sequences belonging to each NHANES III participant and a recipient known to have been infected before transplantation are marked by separate shaded regions. The size of each shaded region represents the genetic diversity of quasi-species from that specimen or group of specimens. Isolates belonging to the donor and 8 case-patients are clustered together. Unrooted phylogenetic tree of hypervariable region sequences of graft donor, graft recipients, and selected Third National Health and Nutrition Examination Survey (NHANES III) participants, United States, 2000–2002.
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