Screening Primary Care Patients for Hereditary Hemochromatosis with Transferrin Saturation and Serum Ferritin Level: Systematic Review for the American College of Physicians

  1. Brian Schmitt, MD, MPH;
  2. Robert M. Golub, MD; and
  3. Richard Green, MD
  1. From Loyola University Medical Center, Maywood, Illinois; Hines Veterans Affairs Medical Center, Hines, Illinois; and Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    1. Appendix Figure 1.
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        Appendix Figure 1. The selection and exclusion of articles to address subquestion 1 about the prevalence of hereditary hemochromatosis.
      • Appendix Figure 2.
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          Appendix Figure 2. The selection and exclusion of articles to address subquestion 2 about the magnitude of complications with primary iron overload (biochemical measures).
        • Appendix Figure 3.
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            Appendix Figure 3. The selection and exclusion of articles to address subquestion 2 about the magnitude of complications with primary iron overloading (iron deposition).
          • Appendix Figure 4.
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              Appendix Figure 4. The selection and exclusion of articles to address subquestion 3 about the diagnostic usefulness of transferrin saturation and serum ferritin level.
            • Appendix Figure 5.
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                Appendix Figure 5. The selection and exclusion of articles to address subquestion 4 about the treatment of hereditary hemochromatosis.

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