Subungual Splinter Hemorrhages: A Clinical Window to Inhibition of Vascular Endothelial Growth Factor Receptors?

  1. Caroline Robert, MD, PhD;
  2. Sandrine Faivre;
  3. Eric Raymond;
  4. Jean-Pierre Armand; and
  5. Bernard Escudier
  1. From Institute Gustave Roussy, 94800 Villejuif Cedex, France.

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    TO THE EDITOR:

    Background: Over the past few years, cancer therapy has been profoundly changed by the development of drugs targeting specific kinases involved in the proliferation of tumor or endothelial cells. Some kinase inhibitors exhibit antiangiogenic activity by targeting vascular endothelial growth factor receptors (VEGFRs).

    Objective: We report the …

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